Clinical Significance of Hepatitis C Virus Genotypes
نویسنده
چکیده
INTRODUCTION .......................................................................................................................................................223 GENOMIC ORGANIZATION OF HCV..................................................................................................................223 GENOMIC HETEROGENEITY AND CLASSIFICATION SYSTEMS ..............................................................224 ROLE OF GENOMIC HETEROGENEITY IN HCV PERSISTENCE AND VACCINE DEVELOPMENT.............................................................................................................................225 METHODS FOR HCV GENOTYPING...................................................................................................................226 Molecular Genotyping ............................................................................................................................................226 Serologic Genotyping..............................................................................................................................................226 GEOGRAPHIC DISTRIBUTION OF HCV GENOTYPES...................................................................................227 CLINICAL RELEVANCE OF HCV GENOTYPES................................................................................................228 Genotypes and HCV Genetic Heterogeneity as Epidemiologic Markers ........................................................228 HCV Diagnostic Assays..........................................................................................................................................229 Outcome of Acute HCV Infection .........................................................................................................................229 Progression of Liver Disease.................................................................................................................................230 Response to Interferon Therapy ...........................................................................................................................231 CONCLUSIONS .........................................................................................................................................................231 REFERENCES ............................................................................................................................................................231
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